Originally Posted by jeffreyn

However, as reported in another research paper [2], in (all?) PWPs the c-Abl enzyme interferes with the normal operation of Parkin.

[1] Matheoud et al. (2016) Parkinson's Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation, Cell 166, 314-327, doi: 10.1016/j.cell.2016.05.039.

[2] Brahmachari et al. (2016) Activation of tyrosine kinase c-Abl contributes to a-synuclein-induced neurodegeneration. J Clin Invest. doi: 10.1172/JCI85456.
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