View Single Post
Old 03-25-2017, 06:07 AM
jeffreyn jeffreyn is offline
Member
 
Join Date: Apr 2016
Location: Australia
Posts: 352
8 yr Member
jeffreyn jeffreyn is offline
Member
 
Join Date: Apr 2016
Location: Australia
Posts: 352
8 yr Member
Default

Tupelo3 said: "You've just described the theory of why c-Abl inhibitors (e.g. Nilotinib) may be neuroprotective."

I would say "a theory" rather than "the theory". There are (at least) several theories.

From my second reference (Brahmachari et al.): "... we report a key and defining role for c-Abl activation in a-synuclein-induced neurodegeneration. In particular, our study implicates that selective inhibition of c-Abl could be neuroprotective."

Here is another one, this time involving the PARIS protein.

Role of Parkin, PINK 1 in protection of dopamine neurons
jeffreyn is offline   Reply With QuoteReply With Quote