Quote:
Originally Posted by jeffreyn
Blackfeather said: ".... an aggegation of alpha synuclean in the brain results in PD."
As Tupelo3 said: "Let's just hope that it actually has efficacy."
IMHO, they might end up (eventually) finding that PD results in an aggregation of alpha synuclein in the brain, rather then an aggregation of alpha synuclein in the brain results in PD.
|
No doubt that there are legitimate arguments for both schools of thought, although the misfolded a-syn aggregation leading to cell death camp is clearly the larger one at this time (neither side having actual proof).
As I said, all of the Alzheimer's research has failed to date. Could be that the drugs just don't work in the cell like they do in cerebral fluid ; could be it attacks the wrong protein ; or it could be that the protein aggregation is just a by-product of the disease and not part of the causal sequence.