Dr Oler is trying to first increase 5HTP and then if that doesn't work he wants to try a dopamine challenge. My husband, who has a strong stomach, just couldn't handle the nausea from the higher dose of 5HTP and had to back down, so he will be contacting Dr. Oler for the next step.
His lab readings before the following recommendations were:
Serotonin 3428
Dopamine 1489
No phases mentioned but both readings are high according to their chart:
Serotonin 0-921
Dopamine 0-670
For his age range of above 50.
Breakfast: Neuroreplete 4, Replete Extra 1-2, D5-40 2
Lunch: Neuroreplete 4, Replete Extra 1-2, D5-40 2
Dinner: Replete Extra 2-4, D5-40 1
Daily: P5P 100 mg, Methionine 4500mg
Notes:
RepleteExtra & Tyrosine capsules – begin by increasing RepleteExtra to 1/1/2 capsules/day and take 4000 mg tyrosine/day and
continue for 10-14 days; if you are still experiencing symptoms, please increase RepleteExtra to 2/2/4 capsules/day and increase tyrosine to 5000 mg/day and continue for 14 days; if you are still experiencing symptoms complete a DBS test and send in (equivalent dosing = Neuroplete – 8, RepleteExtra- 8, D5 Mucuna 40% capsules = 5, CR = 6, B6 = 100 mg)
Equivalent dosing: increase to 5-HTP = 600 mg, L-tyrosine = 4000 mg, L-dopa = 600 mg, methionine = 4500 mg – continue for 10- 14 days; if still experiencing symptoms, please increase to 5-HTP = 900 mg, L-tyrosine = 5000 mg, L-dopa = 600 mg, methionine – 4500 mg – continue for 14 days; if still experiencing symptoms, submit another DBS test and send in (see equivalents above)
• For all dosing levels, take 400 mcg selenium, 800 mcg folate/5-MTHF, 100 mg B6, calcium – 220 mg, l-lysine: 500 mg.
It is very important to get in all the amino acid supplements daily; if you miss a dose, take them at some other time during the day
You can open the NeuroReplete or RepleteExtra capsules and pour into liquid/applesauce if needed; do NOT open the CysReplete
Leave amino acid capsules in your mouth with water 5-10 seconds before swallowing
Water – drink 2-2.5 quarts of water/tea daily in divided doses (4 oz. (1/2 cup) every 30 minutes optimal)
Thanks!
Quote:
Originally Posted by billbobby21
HangOn,
Sorry for the late response, I forgot about this thread but thankfully I remembered it when visiting this site today!
How have things gone with your husband over the last few months? From your last post it sounds like things were going relatively well. When you say he was taking 150 mg 5-HtP, 300 mg of L-dopa, and 1500 mg of L-Tyrosine, do you actually mean he was taking 4 Capsules of NeuroReplete (for the 5-htp), 2 pills of D5 Mucuna a day (for the L-dopa), and a couple pills of TyrosineReplete (for the Tyrosine)? I just am kind of confused as to why you listed what he is taking in that way.
Also did you mention the issues that your husband was having while taking the CysReplete to Dr. Chad? If so, were you able to successfully switch to a Methionine based supplement?
I'd be interested in knowing the specific number values of the tests that he has done as that would indicate the phases and the response he is having, but if you want to keep that information to yourself that is completely understandable.
In regards to your own situation with the RLS, if you are found to actually be dopamine dominant which is done by doing a dopamine challenge. During a dopamine challenge you take 6 D5 Mucuna pills a day for 7 days and see what response you have to it. If you have negative side effects appear, then you would be recognized as not being dopamine dominant and would do the same method of treatment as your husband which is doing tests under the three phase model of treatment. If you tolerate the 6 D5 Mucuna pills with basically no change in how you feel, then you are diagnosed as being dopamine dominant meaning you need high amounts of L-dopa with relatively low amounts of 5-htp for alleviation of symptoms.
The dopamine dominant way of treatment can be quicker/easier or it can be quite a bit more difficult/complicated. It really comes down to how much D5 Mucuna you would need and if any side effects appeared that would need taking care of by adjusting the 5-htp dosing.
I would just make sure to talk through everything with Dr. Chad and then based on what he says and suggests you can make the best decision for yourself. If you have true RLS and not a misdiagnosed condition then doing the amino acid therapy could be of great benefit to prevent any future progression and eliminate any current symptoms.
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