I am so glad to hear you are doing better, and taking less ldopa supplements, but really am puzzled. We got a doctor (took us awhile to find one, but that's another story) who was willing to script us the injectable form of B1 that was the focus of several studies. You inject it into the muscle, which isn't easy to do if you don't like needles! We used the thigh muscle and alternated legs each day. We noticed no difference whatsoever. It was so disappointing because it sounds like it helped so many other PWP.

I can only think that the B1 injected into the muscle isn't as good or synergistic as that you get from food, but the research using the injectable B1 sure did sound promising.

Has anyone else tried the massive doses of B1 that Dr. Costantini used in his patients and if so, with what results? His explanation of why it helps makes a lot of sense, so we don't know why it didn't help us.