Sorry for the slow response Wendy.

I have not adjusted my meds for my long bike rides. I find that following a consistent schedule works best for me. I have a vibrating alarm watch that goes off four times each day. Buzzer goes off; pill goes in. Like. your Telegraph Creek experience, I find that the more I do and the harder it is, the better I get. I don't think I would be riding my bike up a 20% grade however! My longest bike days have been 80-85 miles so I expect your 24 miles, depending on elevation gain, could be quite doable. It sounds like a great trip. We're going to float the Grand Canyon this summer. I don't know how I'll get any biking in, but we'll be doing a lot of yoga!