That is very interesting.

Some background which may be helpful:

There are four biotin-dependent carboxylases in people. Pyruvate carboxylase catalyses the first step in gluconeogenesis, acetyl CoA carboxylase catalyses the first step in fatty acid biosynthesis, propionyl CoA carboxylase is important in the metabolism of fatty acids with an odd number of carbon atoms and methylcrotonyl CoA carboxylase is involved in amino acid metabolism. Pyruvate carboxylase, methylcrotonyl CoA carboxylase and propionyl CoA carboxylase are mitochondrial while acetyl CoA carboxylase is found in mitochondria and in the cytosol.