Hi madmax80

The IVS20DS variant of IKBKAP is relatively common in people of Ashkenazi Jewish background and can lead to sensory neuropathy. The "Molecular Genetics" section here might help you in discussing this with your health care team OMIM Entry

- * 63722 - INHIBITOR OF KAPPA LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS, KINASE COMPLEX-ASSOCIATED PROTEIN; IKBKAP.

Acrokeratosis verruciformis is an autosomal dominant condition associated with mutations in the ATP2A2 gene. What that means is that it has a strong family genetic history - if one of your parents (and either of their parents, etc) has it then there is a 50:50 chance that you will.

The information here might help you in this context Acrokeratosis Verruciformis of Hopf: Background, Pathophysiology, Epidemiology.