We were told Nuplazid is a serotonin blocker, which is good because it doesn't negate the levodopa needed to move. What dose would one need to take Trazodone to equal Nuplazid?

I understand Trazodone is an old antidepressant which is now used offlabel for sleep issues-we have been scripted this as well for sleep but at 50mg noticed no effect and quit taking it. I think imark on this forum takes much more for sleep, 300mg, so our dose was admittedly very low and we may discuss this at the next neuro appt.

We have had several neuros tell us that the hallucinations can be caused by the drugs-both sinemet and mirapex (agonists)-but if you reduce those you lose mobility, a crappy trade off and at some point unacceptable.....and can also be caused by PD itself, in which case reducing sinement/agonists won't help much.

I am sorry to hear your wife is having such a hard time. That is so difficult and no doubt very scary for her.