Notsohappy, I do not think that you are stupid.

Often inflammatory responses have an immune system involvement. The immune system is very complicated; many different kinds of cells, many different proteins, all interacting with each other in poorly-understood complex ways which can be affected by things like prescription drugs.

A specific example of this is a sadly now-deceased friend of mine who lived with Crohn's Disease for many years. Crohn's Disease is a primarily inflammatory condition with some immune system involvement.

She quite often had flares which neither she nor her very good health care team could explain.