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Old 05-09-2017, 10:38 AM
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kiwi33 kiwi33 is offline
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kiwi33 kiwi33 is offline
Grand Magnate
kiwi33's Avatar
 
Join Date: Jan 2015
Location: Sydney, Australia.
Posts: 3,093
8 yr Member
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"Not sure why my general doctor sent these tests but LAMBDA returned low as 2.41 on the scale of 6-26, KAPA returned normal. "

Madmax80, lambda and kappa light chains occur in two contexts. All antibody molecules contain two identical light chains (either lambda or kappa) together with two identical heavy chains, which come in five different classes. As far as I know, variations in the proportions of antibodies with lambda or kappa light chains have no clinical significance.

Both lambda and kappa light chains can also occur free (not as part of antibody molecules). Elevated levels of either can indicate a range of health problems.

I doubt that the fact that your free lambda level is low but free kappa is normal is a matter of concern.

The information here might help you to discuss this with your general doctor Serum free light chain assays not total light chain assays are the standard of care to assess Monoclonal Gammopathies.
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