Originally Posted by mrsD

The most common is lidocaine. Some people get infusions IV of this. We used to have poster from Scotland who did them.

CV Pharmacology | Sodium-Channel Blockers (Class I Antiarrhythmics)

An oral one is mexiletine which some on this forum have posted about. Its side effects on the stomach and esophagus however are severe and almost half who try it cannot tolerate it. It can actually
erode the tissues there.

Sodium channel blockers affect the heart and sometimes are used for arrhythmias and this is why the research is bogged down with these agents and slow. These drugs can cause sudden death and are only used today as a last resort.