Quote:
Originally Posted by madisongrrl
I have both the know-how and access to the proper equipment (former chemist) to do something like this.....and I probably would not attempt it.
If you don't have access to the tools, access to the specific recipe in the study, or the ability to test the potency or stability, it's not worth it.
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thank you for the reply, I will copy-paste this study I found, I would love to hear your opinion:
Topical gabapentin in the treatment of localized and generalized vulvodynia.
Boardman LA1, Cooper AS, Blais LR, Raker CA.
Author information
Abstract
OBJECTIVE:
To evaluate the clinical efficacy and tolerability of topical gabapentin in the treatment of women with vulvodynia.
METHODS:
A retrospective study was designed to ascertain clinical responses to topical gabapentin. Patient demographic and medical characteristics, including present and prior treatment for vulvodynia, were routinely collected. The final outcome was defined by a comparison between pretreatment and posttreatment mean pain scores based on a discrete visual analog scale of 0 to 10. Categorical data were compared by Fisher exact test, continuous variables between groups by the Wilcoxon rank sum test, and mean change in pain score between pretreatment and posttreatment by paired Student t test.
RESULTS:
Between January 2001 and December 2006, 51 women with vulvodynia (19 or 37% with generalized vulvodynia, 32 or 63% with localized) were treated with 2% to 6% gabapentin. After a minimum of 8 weeks of therapy, the mean pain score among the 35 evaluable women was significantly reduced from 7.26 to 2.49 (mean change -4.77, 95% confidence interval -5.47 to -4.07). Overall, 28 of 35 (80%) demonstrated at least a 50% improvement in pain scores. Among patients with localized vulvodynia, sexual function improved in 17 of 20 with evaluable results (6 of 9 reinstituted vaginal intercourse, whereas all 11 patients experiencing decreased frequency of intercourse reported increased frequency after treatment). Discontinuations occurred in 7 of 50 (14%) treated.
CONCLUSION:
Topical gabapentin seems to be well-tolerated and associated with significant pain relief in women with vulvodynia.
LEVEL OF EVIDENCE:
III.
Source:
Topical gabapentin in the treatment of localized and generalized vulvodynia. - PubMed - NCBI
My problem is actually that my amitriptyline isn't working fast enough, it takes months to achieve full remission of symptoms and my GP which I hate keeps postponing giving me the Lyrica which works very fast and very well for me. I kept trying to talk to her and she says she wants to wait bla bla