@ work i use a desktop, but find myself using my left hand (esp. the ring and pinkie fingers) way too much.

@ home, I usually use a desktop, because the laptop made all of those small motor things difficult- like you said - how do you hold a book correctly. However. right now i'm back to the laptop b/c the desktop decided to give me a diskette drive 0 seek failure (even tho i haven't had a "diskette drive" in forever. just one more thing to figure out how to fix.