Microtablets

Aquilonius and Nyholm write [1]:

"A rapidly soluble tablet formulation containing 5 mg levodopa and 1.25 mg carbidopa was developed (LC-5, named Flexilev® in Sweden)."

"in a cross-over study in healthy volunteers, fractionation of levodopa with Flexilev as compared to standard administration of levodopa/carbidopa/entacapone decreased the fluctuation index of both levodopa and carbidopa in plasma by nearly half ... We have recently confirmed the similarity in levodopa pharmacokinetics in healthy volunteers and PD patients under fasting conditions".

I think the dispensing system is overly complicated, but the microtablets themselves will prove useful.

Reference:

[1] "Development of new levodopa treatment strategies in Parkinson’s disease—from bedside to bench to bedside"
Sten-Magnus Aquilonius and Dag Nyholm
Upsala Journal of Medical Sciences, 2017
Development of new levodopa treatment strategies in Parkinson’s disease—from bedside to bench to bedside

John