my Neuro has been telling me for the last 13 years merry trip down the PD road that PD drugs are best used little and often rather than infrequently and a lot.

I agree with John that you should talk to your Neuro about dosage. 200 mg in a single sitting would clean me out, I take a mix of 100 mg and 75 mg 6/7 times a day.

Also my experience of Sinemet cr was negative, didn't really work for me. Stalevo (a sort of constant release drug) is very good for me. Try to get some smoothing of the dopamine hit rather than all at once which will reduce the Levadopa hit.

Again also, don't knock Dopamine Agonists. They can be used alongside Levadopa and are less likely to produce Dyskinesia. Less likely but certainly not never. I take full dose of Pramipexole and its good for me although some people (usually older PWP), cannot handle the side effects.

Also Amantadyne works great for me at reducing Dysks.

As you can see you have a lot of options open to you. Get into your Neuro and discuss options and I am sure that it will be a worthwhile discussion.

Take care,
Neil.