NAC seems to have a side-effect that may actually be beneficial for some. A couple of guys at HU have reported severe constipation when taking 1800mg/day. One thought was that NAC was causing a "drying out" of the GI tract. For myself (at 1200mg/day) and for someone at HU, NAC seems to have had a beneficial effect on our "urge incontinence" symptoms, possibly for the same reason (i.e. a drying-out effect). I'm happy to keep taking it just for that benefit.

I've been taking NAC for about 5 months. I've also been taking mannitol for about 8 months. I've also been doing 40 mins of high-cadence cycling every day for about 16 months.

Things have been going really well since shortly after I started taking NAC. How much of this can be attributed to NAC, or to mannitol, or to high-cadence cycling (or to some combination of these), is not clear to me.