Hello tkrik,

You need to ask your specialist if your ANA came in positive for Lupus and if so if you have skin involvement besides, as i have Lupus and plaquenil is an Anti-malerial drug mainly to help the skin but it does help joints also.

I'm taking it but only 200mg daily as i also take methotrexate which is a strong chemo med with side affects. When i took the plaquenil at first i was bad with an upset stomach, anxiety attacks was up the wall bad feeling of being enclosed plus feeling sick with nausea so i came off it and the rheumo persisted i needed it, as i also have SCLE of the skin, which i can't wait to post once i've done my 10 posts as i look like i've done 10 rounds in a boxing ring

Someone told me to take it at night as you sleep the side affects of and bingo nothing since and when i was put on the methotrexate the sister told me to do the same for that.

It also sounds to me personally after taking a cocktail of meds for years, your taking to much as it's upsetting your system.

Did you see an opthamologist before taking the drug as your supposed to, to make sure your eyes are ok because some people it affects with the retina.