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Old 09-05-2017, 02:07 AM
jeffreyn jeffreyn is offline
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Join Date: Apr 2016
Location: Australia
Posts: 352
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jeffreyn jeffreyn is offline
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Join Date: Apr 2016
Location: Australia
Posts: 352
8 yr Member
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It has taken a while, but the Journal of Innate Immunity has now published an editorial [1] that discusses the Stolzenberg et al. paper [2].

As Labrie and Brundin say in the final paragraph: "... it will be important to understand what mechanisms are responsible for modulating pathogen-induced alpha-synuclein increases in the gut" i.e. how the alpha-syn is normally cleared (and what stops that from happening in PD).

https://www.karger.com/Article/FullText/479653

[1] Alpha-Synuclein to the Rescue - Immune Cell Recruitment by Alpha-Synuclein during Gastrointestinal Infection, Viviane Labrie & Patrik Brundin, J Innate Immun 2017;9:437–440.

[2] A role for neuronal alpha-synuclein in gastrointestinal immunity, Stolzenberg et al., J Innate Immun 2017; 9:456–463.
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