My doctor ordered the pyridostigmine Br Extended Release for me now, to replace the regular 60mg pills I was taking 4-5 times a day.

Now that I have bottle in hand, I called the manufacturer about whether it is okay to cut it in half or not. The pills are scored, "functionally scored" is the official wording on their literature.

What I have is Alvogen Pyridostigmine Bromide Extended-Release Tablets 180mg. Alvogen's customer service line has told me that yes, you can cut the tablet in half to get effectively a lower dose ER pill. IF stored properly, which means in a tightly sealed dark container with dessicant present, to protect it from humidity and light, a cut tablet is good for up to 90 days from the date it was cut.

So, for Alvogen Pyridostigmine Br Extended-Release Tablets that are functionally scored, the answer is YES, you can halve them.

If you have another brand/manufacturer, I would suggest looking up their customer service phone number online, and calling and asking.