KNPV,

Some possible reasons for not noticing any differences when taking levodopa:
- your symptoms are so mild that "normal" is little different;
- your dose is too low to take you over the therapeutic threshold;
- the absorption of the dose is affected by protein in your diet;
- you don't have PD.

Sometimes I will "lose" a dose: it just has no effect. Other than thinking that it may be linked to constipation, which I suffer from badly, I don't know the cause of this.

To measure your PD you can do a side-to-side tap test.

Parkinson's Disease Measurement: PwP, surveys, trials, analysis

There's a definite learning effect. So, do the test 10 times and throw away the results. Then do the test immediately before a dose and again 60 minutes later. Adding together the left and right hand components gives me a total score of about 40 when I'm "off" and about 60 when I'm "on".

John