Quote:
Originally Posted by johnt
Thank you for highlighting the supply problem. I've not heard of any problems in the UK - yet.
One issue with breaking up a levodopa/carbidopa CR pill is that it increases the bioavailability of levodopa by about 30%. Normally, as a CR pill is sitting in the stomach providing no therapeutic benefit for now, it is slowly being disintegrated and the freed levodopa starts being metabolized. It is only when the levodopa gets to the upper intestine that it begins to get absorbed.
So, watch out for things like hypotension and dyskinesia, and be ready at the end of the drug cycle for a faster "off".
John
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john, i was testing if 1/2 of a 50/200 chewed up would substitute in a pinch for a 25/100. would it kick in in about the same time, have the same affect? it was close. so i wanted increased bioavailability from chewing it up. it's not going to have more l-dopa becoming available than a 25/100. fwiw, i also chewed some gum after chewing up the CR, it sticks to your teeth
