Kay,
One thing that would work for me is to make a tally mark on a calendar
or piece of paper that I taped to the fridge or notebook or white board.
Twenty Tally T-Shirt | Spreadshirt
For example if I already made a check mark for a.m. meds I would know that
I took my meds.
A friend of mine had a system of turning the pill bottles upside down after
she took them.
Or a fridge magnet that one could turn upside down or move from the right to
the left side of the refrigerator.
Also, consider a phone app:
Medisafe Meds & Pill Reminder - Android Apps on Google Play
You already have figured out that color and space would help.
I am simply sending these ideas your way in case they are helpful.
M