I didn't try zonisamide for very long so I really can't offer any information on its effects. I had a medical crisis at the time i was just beginning to try zonisamide. This was unrelated to zonisamide. My bladder shut down and I developed a UTI. I was very close to having kidney failure and was hospitalised. After that experience I decided to try other treatment protocls for my PD. I still have my zonisamide if I ever decide to try it.