This is fascinating research, but I'm not sure that I see how regulating the signaling of dopamine-secreting neurons helps us except as to perhaps mitigating side effects of sinemet like dyskensias.

If researchers are right and PWP have lost a large number of their dopamine-secreting neurons, then how will managing how frequently those neurons secret dopamine help? Seems like we still have the fundamental issue of not enough dopamine to begin with, because we've lost so many of those neurons.

Or maybe they aren't seeing this as a cure, but rather a possible treatment to help make the most of the dopamine we make and get externally from sinemet.

What am I missing?