neupro contains a dopamine agonist called rotigotine (so not mirapex or requip and don't try taping pills to your forehead, etc. or snorting them

https://www.accessdata.fda.gov/drugs.../021829lbl.pdf

because it is an agonist you only need upto 18mg/day to diffuse thru your skin and that's doable because of the structure of the patch in opening up tiny holes in the skin. if l-dopa could be delivered at a fast enough rate thru the skin a patch would have been developed years ago and i kind of doubt much effort would have gone into developing the incredibly expensive gel delivery systems that have come out recently and for which the drug companies expect to rake in at least $30,000/year for their patented gel formulation of C/L The first FDA approved device is called dupodopa which is available using an external pump which is carried in a lunchbox size carrier. the newer medical device that bypasses the stomach is a small modified insulin pump that requires no surgery like the duopa system, with that system the stomach is completely bypassed via a tube inserted thru the stomach wall and into the small intestine with the gel C/L delivered close to the area in the small intestine where absorption of C/L into the capillaries is the maximum. drug companies luv patches, generic companies have to put in more resources and develop the skills to make a patch so greater chance no generic would be made, the brand name company can lower their price if needed. to repeat, drug companies have made a lot of patch systems for many different drugs, if the properties of the skin and l-dopa allowed enough l-dopa to pass thru the skin to allow a useful constant delivery we'd all be wearing small patches rather than the body length patches we would need.

Transdermal patch - Wikipedia
Positive Results for Levodopa/ Carbidopa ‘Pump Patch’ | Parkinson's Disease


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