John my son endedup with debilitating anxiety , depression, ruminating thoughts etc. he had several concussions and had post concussion syndrome for some years. an HRT doc who works with concussion patients treated him and his anxiety is at normal levels and depression is gone. his constant panic attacks are gone also. he used to describe them to me as very powerful and physical. after he started his hrt therapy i did some research and found testosterone forums with others who also agreed that low testosterone or high test or low or high estradiol caused them panic attacks also. the hormone issues can be caused by stress or trauma and in some individuals the HPTA axis does not reset to correct. its worth getting your levels medically checked. my son faced a lifetime of medication..