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Old 03-07-2018, 02:38 PM
johnt johnt is offline
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Join Date: Apr 2009
Location: Stafford, UK
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15 yr Member
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
15 yr Member
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Similar conclusions were quoted in a recent thread:
Widening the scope and the extent of PD therapy

'Qamar et al. write ...:

"Besides dopamine (DA), three further key neurotransmitters have been described to be involved in the pathogenesis of PD; namely noradrenaline (NA), acetylcholine (ACh), and serotonin (5HT)."'

It doesn't seem unreasonable to think of Parkinson's as a neurotransmitter disease, rather than just a lack of dopamine disease. Moreover, the standard dopamine replacement therapy is throwing exogenous levodopa across the whole brain, which must have some effect on other neurotransmitters.

Levodopa does a good job with motor problems, but does little to address non-motor symptoms such as constipation.

John
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
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"Thanks for this!" says:
jeffreyn (03-07-2018)