I took Cipro and Flagyl in combination while suffering from Diverticulitis several years ago. I had many attacks in a one year period and was on these antibiotics for 3 weeks during every attack. I had no side effects from the drugs at the time (no quick onset), and surgery eventually provided relief from the DV, but over time, my PN came on and then progressed. I often wonder if the antibiotics were the cause? I have no way of knowing, but I do know that those medications saved my life during the attacks. If they were the cause of the PN, I suppose it's the price I had to pay...