From time to time I get the kind of "off" feeling like you are describing. I have a lot of paresthesias/dysthesias from MS, and the feeling I get is a little different. It feels like a med error/over-medication.
I can understand why you would want to cut back on the dose of one or more meds in response to this kind of experience. Things like that make me want to reduce my dose of gabapentin, but I know I need it.
I'm glad that you have made adjustments to help you avoid some of the bull s*** in life