My husband had a good response to Alpha Lipoic Acid. I think he was taking 600 MG/2Xday. This was before R-lipoic acid was available.

I would up the dosage of B12 and look at replacing the folic acid with a good bio-available B complex that has the active form of folate as well as the other B vitamins.

Also, look into adding K2 with your vitamin D3. The K2 helps the calcium get to where it belongs.