View Single Post
Old 08-25-2018, 04:06 AM
RooJr RooJr is offline
Junior Member
 
Join Date: Sep 2015
Posts: 32
8 yr Member
RooJr RooJr is offline
Junior Member
 
Join Date: Sep 2015
Posts: 32
8 yr Member
Default

Quote:
Originally Posted by johnt View Post
I can only find the Abstract describing this research:
https://www.iaprd-world-congress.com..._Abstracts.pdf

The conclusions:

"a single time oral administration of Nilotinib may increase brain dopamine levels and metabolism. These results suggest Nilotinib, in a dose dependent manner, may have a symptomatic effect through modulation of brain dopamine levels. Additionally, the significant reduction of oligomeric alpha-synuclein, which is expected to increase in the CSF of PD patients as the disease progresses, suggests that Nilotinib may reduce misfolded alpha-synuclein accumulation and have a longterm disease modifying effect. Importantly, the dose response of oligomeric alpha-synuclein and HVA changes to nilotinib suggests that the dose administered may depend on the stage of disease to potentially halt PD progression."

John
Great Find!
RooJr is offline   Reply With QuoteReply With Quote