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Old 09-16-2018, 07:15 PM
Tupelo3 Tupelo3 is offline
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Tupelo3 Tupelo3 is offline
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Join Date: Mar 2013
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Quote:
Originally Posted by johnt View Post
I can only find the Abstract describing this research:
https://www.iaprd-world-congress.com..._Abstracts.pdf

The conclusions:

"a single time oral administration of Nilotinib may increase brain dopamine levels and metabolism. These results suggest Nilotinib, in a dose dependent manner, may have a symptomatic effect through modulation of brain dopamine levels. Additionally, the significant reduction of oligomeric alpha-synuclein, which is expected to increase in the CSF of PD patients as the disease progresses, suggests that Nilotinib may reduce misfolded alpha-synuclein accumulation and have a longterm disease modifying effect. Importantly, the dose response of oligomeric alpha-synuclein and HVA changes to nilotinib suggests that the dose administered may depend on the stage of disease to potentially halt PD progression."

John

Yes, as Jeff replied, this was only presented as an Abstract at the Oral Poster Presentation of the 2018 iaprd. This is a common occurrence to present abstracts and posters of ongoing clinical resesrch to provide updates as data is analysed.
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