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Old 10-16-2018, 05:57 PM
johnt johnt is offline
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Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
10 yr Member
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
10 yr Member
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moondaughter,

You ask about the timing of high tap test scores (lower symptoms). This will depend on your medication regimen, your endogenous dopamine production, your exercise and your diet.

So far your experimentation has been in the area of pharmacodynamics (what the drug does to your body).

But, you may wish to explore the pharmacokinetics (what the body does to the drug) of your drug regimen. I have written an app to do that:

Parkinson's Disease Measurement: PwP, surveys, trials, analysis

This draws a graph of levodopa equivalent plasma levels on a minute by minute basis throughout the day. See examples of the output from that app in the recent thread:

Sunovion Expects APL-130277 Will Ably Treat Off Episodes, Awaits FDA Decision

You can enter the data describing your own regimen, and also play "what if" by moving around doses and timings etc..

Please note that this is just a mathematical model implementing a theory, a simplification of the real-world. But, it may be sufficiently accurate to give you some pointers as to how to go forward.

John
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
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"Thanks for this!" says:
moondaughter (10-16-2018)