When I first began taking sinemet it was 3 months+ before I felt the whole impact- but then I had been symptomatic for 16+ years previous to taking an pd med- now 24+ years of sx cycling back and forth with the seasons.

My theory is its best to take minimum dose but not to the point of under medicating. With early onset it just seems important to resist flooding receptors- is this a flawed perspective? I used to start my first dose of the day at 7 AM but now can wait till 9-10 AM..also find that the last dose taken in late afternoon carrys me really well into the night

What is counter intuitive is that as the sinemet/mucuna become less effective smaller doses function as well or better as higher doses unless I go too long without keeping the med effect fairly continuous.

MD