Are there others here that are using Thiamine and do they see any positive results?

This paper states that Thiamine doses of several grams were used in tests.



Thiamine Deficiency and Neurodegeneration: The Interplay among Oxidative Stress, Endoplasmic Reticulum Stress and Autophagy


PD is the second most common form of neurodegeneration in the elderly population, characterized by resting tremor, rigidity, slowness of movement, and postural imbalance [63]. It affects more than 1% of individuals older than 55 years of age and more than 3% of those older than 75 years of age [64]. The loss of dopaminergic neurons in the substantia nigra is a major pathophysiological feature of patients with PD [65]. Several lines of evidence have shown that thiamine or thiamine-dependent processes may be involved in the pathogenesis of PD. For example, lower free thiamine levels in the cerebrospinal fluid were found in PD patients in comparison to normal individuals, while levels of thiamine-derivatives, such as thiamine-diphosphate and thiamine-monophosphate, did not differ significantly [66]. Additionally, the immunoreactivity of KGDHC, one of the most important thiamine-dependent enzymes, was decreased in the substantia nigra of patients with PD, and the reduction seemed correlated with the severity of degeneration [67, 68]. In some studies, thiamine supplementation seemed to improve the outcomes for PD patients. For example, administration of parenteral high-dose thiamine was effective in reversing motor and non-motor symptoms in PD patients [28, 30]. These findings suggest that TD may be involved in the pathophysiology of PD.