I am looking to see if anyone or a family member with Parkinson's has the same problem as my mother. She was diagnosed with early onset PD about 25 years ago. She has done ok, until the last couple of years the meds don't seen to work as well for her. She is already on a fairly high dose of Rytary. Her PD is more rigidity and extreme fatigue (some balance). The meds allow her to be active and mobile. My question is in regards to "off" times. I have read about how there is some "off" time between doses. However, my mother says that there are some days her meds work better than others. On bad days she mostly wants to lay in bed and is very depressed. On good days, she wants to go non-stop, even to her own detriment. On bad days she can't go as long between doses, on good days she can go farther. Just looking for perspective to better understand what she is going through so I can help her. Thanks.