Welcome to my world.

The only way I deal with these is by work-arounds and other accommodations.

I don't even try to read large blocks of text. Even healthy brains struggle with them. Line lengths in excess of 80 characters are not reasonable, even to healthy brains. The brain stops comprehending at 80 characters or less.

Vision, nystagmus (not curable) and such make it difficult to follow from one line to the next.

Don't try to fight these. Find a work around.

Use a blank sheet of paper above and below on large blocks of text if they are on paper.

You don't mention the differences between on a compouter screen and on paper. There can be a huge difference.

Subtitles are miserable because they jump. A transcript is much better. You need to be able to read at your pace, not the pace of the closed captioning.

Read my post about struggles to read web content. Please post your specifics there.

In the US, these are ADA issues.

I am trying to fight this at the federal level. Web based content has become impossible in the past few years.