Steve and Chris, we seem to be on the same page. Same age, dxs at approximately the same time and having trouble with dystonia and fatigue. I am currently taking Sinemet 25/100 4 x a day, and 14 mgs. of requip a day. In April my MDS switched me to 4 x a day because I had end of dose dystonia after about 3 hours. I push myself to do too much and often feel that I have over done it. Chris, you will probably find you do much better now that you aren't going to work. Stress is not a good thing besides you should take time for yourself now. I find that sleep and exercise have a great impact on how I feel, we need lots of both.