Is it the isolate tincture and not the powder? With the tincture, you place some under your tongue and hold for a few minutes. You can start low and slowly increase the dose. There's no real way to know how much to take. It's very safe and you can't really overdose. Maybe start with 15-30mg and go from there. It all depends on your body weight and what you're treating. Chronic pain needs more, so do larger people.