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Old 07-23-2007, 09:16 PM
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reverett123 reverett123 is offline
In Remembrance
 
Join Date: Aug 2006
Posts: 3,772
15 yr Member
reverett123 reverett123 is offline
In Remembrance
reverett123's Avatar
 
Join Date: Aug 2006
Posts: 3,772
15 yr Member
Default ircadian rhythms are a sleeper issue in PD

Get it? "sleeper?" Get it?

OK, so they can't all be great ones. But circadian rhythms run the whole show. It has recently been discovered that every cell in the body has a clock just vibrating away and each of those clocks is synchronized by a master clock in the brain. The master clock, in turn, is set by light.

I notice that if I get up at 2:00 AM my functioning is a lot worse than if I get up at 4:00 AM. I really don't think that it is just a matter of dopamine production but also a matter of receptor sensitivity and also cortisol rhythms.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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