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Old 07-13-2019, 03:32 AM
johnt johnt is offline
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Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
15 yr Member
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
15 yr Member
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toyl,

I'm sorry to hear of your problems.

The fact that you are having the "worst dyskinesia" suggests that the new pills are stronger (a higher CMAX than usual). And, the fact that you have shorter "on"/"off" transitions suggests that THALF is less.

The regulatory system demands bioequivalence, but this is interpreted rather loosely. Very roughly speaking this allows about a 5% difference.

See the thread:
Sun Pharmaceuticals new supplier

Last year I measured the weight of my pills (Stalevo in my case) and found inter-batch differences and intra-batch differences of 4%. Note that's the total weight of the pill, not the weight of the active ingredients.

Weighing tablets

After what dose are you having dyskinesia? You may find benefit spreading out your doses. Similarly, with the strong transition, perhaps eating a little fat with the dose may extend the half-life.

John
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
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