Treatment with APLENZIN can result in elevated blood pressure and hypertension. Assess blood pressure before initiating treatment with APLENZIN, and monitor periodically during treatment. The risk of hypertension is increased if APLENZIN is used concomitantly with MAOIs or other drugs that increase dopaminergic or noradrenergic activity [see CONTRAINDICATIONS].

This might explain why my blood pressure went so high. With extra medication my blood pressure is okay. This is the only drug that works for my depression.