Quote:
Originally Posted by EricTheRead
What causes Myasthenia Gravis?
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One risk factor for MG is inheriting specific forms (alleles) of proteins called HLA-DR3 and/or HLA-DR5.
The HLA proteins are important in the immune system. HLA-DR3 and HLA-DR5 can facilitate production of antibodies which recognise the acetylcholine receptor. These "autoantibodies" can cause destruction of this receptor at neuromuscular junctions, which is very common in MG.