Hi Suzie. I didn't have itching when I started taking half of the Seroquel. I went from 600 mgs to 300 mgs at night. I had rage after a job that I had for 14 1/2 years also. I was in a toxic environment at work. It took me a couple of years to cool down. I was angry. Very angry, and upset. I have cooled down. Brokenfriend