Hiya. Here is my experience using oxybutynin patches:

--I used the patches for 6 months and stopped taking my regular meds
--During the time I was on it, my PN symptoms seemed to improve; however, they did not completely disappear. Calf fasciculations remained as did periodic buzzing and itching on my thigh. That said, these symptoms were tolerable, and, for the most part, I was doing well with less noticeable symptoms and without meds.
--There are side-effects if you exceed the one patch dose that are not to be ignored, including cognitive
--Once I came off the patches, I went through a highly stressful period including international travel; in retrospect, this was a BAD time for me to stop the treatment
--My symptoms got worse again within a month of coming off the patches and probably somewhat worse than they had been prior to the experiment
--I am now back on notriptyline and doing much better

On balance, it is difficult to draw conclusions. I don't know how much the improvement I felt was due to placebo, springing from the hope it inspired. And, although the timing I stopped the treatment was really unfortunate, one would have thought the results might have been more enduring than they were if Oxybutynin is really efficacious in actually healing damaged nerves.

Obviously pirenzipine is the preferred option, particularly if applied topically.