When I was taking prednisone I took it all in the morning. It helped with sleeping at night. In fact I would argue against taking prednisone before bedtime. Of course the Mestinon needs to be spread out over the course of the day. There is no interaction between the two. I think the prednisone needs to be taken with food. Prednisone may make you feel a little worse before you feel better. Have your husband take all of the prednisone in the morning and see if he isn’t feeling better by the time you see his neurologist.