Hello moondaughter

Sorry for the delay in answering.

My opinion comes from neurologists and from the experience of the participants of my forum, "Parkinson's Here and Now" (in Spanish). My father never dared to take any vitamins.

In many ways, we are moving into uncharted territory.

There is hardly any information. Some recommend taking them all away from the dose of synthetic or natural levodopa. Others divide them into three doses and take them with the main meals.

If you take mucuna (without carbidopa), I think you should separate the B6 from the others and take it as far as possible from the Mucuna intake and increase the dose little by little.

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As for the interference with levodopa:

B1, no problem. Studies by Luong and Nguyen, Costantini, etc.
B2, either. Coimbra in 2003 used 30 mg three times a day for months and achieved an improvement of 44-71 %.
B3, no problem because it is recommended to improve the absorption and duration of the effect of levodopa.
B6, there are neurologists who set the limit at 25 mg. This seems to me to be the safest, as it agrees with the comment in the levodopa leaflets (since carbidopa is added, 10-25 mg is not a problem).
B9, I have not read any information about problems.
B12, either.

As for the caution with the vitamin itself:

B3 with the dose, because it could cause flushing.
B6, with caution because there are very sensitive people who perhaps with 5-10 mg already reach their maximum.
B12, because some supplements have a lot of quantity and could produce headache.

My reference is the neurologist Ahlskog, who has repeated the recommendation in successive editions of his book to control homocysteine:

25 mg of B6.
2.5 mg of B9.
2 mg or 2000 mcg of B12.

Although it is always advisable to consult a specialist, I think it could be a good choice:
- foods rich in the different B-group vitamins (nuts like pistachio or California nut);
- natural supplements like brewer's yeast;
- and some vitamin and mineral supplements with moderate amounts.

For some more potent supplements I would be very careful. There are some that include 100 mg of vitamin B6. And as they say in my country: neither one nor the other. Neither prohibit even eating pistachios (as my father was told), nor take 100 mg (much higher amounts have been used in studies for dyskinesias by neuroleptics, but to use it along with levodopa I don't know). If I had Parkinson's, I wouldn't dare. Especially not with Mucuna.

Kind Regards,