Rhod, Taking all of the prednisone in the morning may help with all the tiredness. Also, has your husband had his fasting glucose checked? Higher blood sugar is a side effect of prednisone. There is also the idea of adding either Imuran or Cellcept to the drug mix. These are immunosuppressants, but they take some time to kick in. There is also IVIg if you have good insurance. This kicks in a lot faster. For what it’s worth, I also had my legs give out a few times. Jim