I hate to post this news because some people here may be taking Ocrevus or hoping to take it soon. PML is a rarely occurring "adverse event" for some of the MS drugs, and now it seems that Ocrevus is among them. Earlier cases of PML in patients on Ocrevus were thought to have occurred because those patients had been on other MS drugs before Ocrevus. This new case, which ended in death, was in a patient for whom Ocrevus was the first MS drug.
Quote:
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Eight other cases of PML diagnosed after ocrelizumab initiation are considered carry-over cases related to prior treatment with natalizumab or fingolimod, according to Genentech, the manufacturer of ocrelizumab.
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The quote is from this article in Medscape (April 30, 2020):
Report Details First Case of PML With Ocrelizumab Alone
The abstract of the report mentioned in the Medscape article:
2020 American Academy of Neurology Abstract Website